P3996 : In younger people waist circumference below IDF abdominal obesity threshold is associated with other components of metabolic syndrome. Study of families of patients with premature coronary disease

Authors:
M.V. Konnov (Moscow /Russian Federation), L.M. Dobordzhginidze (Moscow /Russian Federation), A.D. Deev (Moscow /Russian Federation), N.A. Gratsiansky (Moscow /Russian Federation)

Topic(s):
Metabolic syndrome / Obesity

Citation:
European Heart Journal ( 2009 ) 30 ( Abstract Supplement ), 655

Objective: To elucidate whether intermediate (I) waist circumference (WC) 72-79 cm, women, 84-93 cm, men - a range just below IDF abdominal obesity threshold is associated with worse risk factor profile than smaller WC.

Methods: In a study of risk factors in families of patients with premature coronary heart disease we selected 251 persons (74 spouses, 177 children of patients) aged ≥16 years without vascular disease with WC ≤79 (women), ≤93 (men) cm, body mass index (BMI) ≥18.5 kg/m². Factors analyzed included BMI, systolic/diastolic BP, serum low density and high density lipoprotein (LDL, HDL) cholesterol (CH), triglycerides (TG), glucose (GL). High BP was defined as prehypertension or hypertension (NHLBI report on high BP in children/adolescents or JNC 7 depending on age). TG≥1.7, GL≥5.6 mmol/l were difined high, HDLCH <1.03 (men), <1.29 mmol/l (women) - low. Framingham risk score was calculated for persons aged ≥30 years. Factors associated with IWC were selected by logistical regression `univariate' analysis with age, sex adjustment. Subjects were divided in 2 age groups: 16-26 years (n=128, 25% with IWC) and 27-62 years (n=123, 56.1% with IWC).

Results: In the whole group IWC was significantly related to high BP and TG. In younger age group persons with IWC had significantly higher risk to have high BP and low HDLCH than those with “normal” WC (table). In older subjects IWC and studied risk factors were not significantly related.

Conclusion: In younger people WC smaller than IDF thresholds can be associated with factors known as components of metabolic syndrome.

Results of univariate analysis

Dependent variables	OR	95% CI	P	Rspearman	Pspearman
16-26 years (IWC, n=32/128)
High BP	2.457	1.307 - 4.621	0.0053	0.21506	0.0156
High TG	5.361	1.326 - 21.676	0.0185	0.20938	0.0186
Low HDL-C	2.707	1.113 - 6.585	0.0282	0.19991	0.0248
High GL	3.049	0.611 - 15.216	0.1740	0.11902	0.1844
27-62 years (IWC, n=69/123)
High GL	0.450	0.098 - 2.059	0.3036	-0.0994	0.2781
Low HDL-C	0.734	0.290 - 1.854	0.5125	0.00439	0.9622
High TG	1.695	0.182 - 15.761	0.6426	0.12735	0.1639
High BP	1.122	0.594 - 2.120	0.7226	0.04938	0.5907