MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01CBC1AC.50696050" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01CBC1AC.50696050 Content-Location: file:///C:/9112A2A7/PREDICT-rus-abst-genes-CAD-Rosenberg.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Многоцентl= 8;овая валидизациn= 3; (проверка) ди&#= 1072;гностическ= ой точности теста на экспрессию генов для оценки выявления обструктивl= 5;ой коронарной болезни у пациентов без диабета</ti= tle> <o:SmartTagType namespaceuri=3D"urn:schemas-microsoft-com:office:smarttags" name=3D"stockticker"/> <!--[if gte mso 9]><xml> <o:DocumentProperties> <o:Author>N.A.Gratsiansky</o:Author> <o:Template>Normal</o:Template> <o:LastAuthor>N.A.Gratsiansky</o:LastAuthor> <o:Revision>5</o:Revision> <o:TotalTime>30</o:TotalTime> <o:Created>2011-01-31T22:02:00Z</o:Created> <o:LastSaved>2011-01-31T22:06:00Z</o:LastSaved> <o:Pages>1</o:Pages> <o:Words>1077</o:Words> <o:Characters>6141</o:Characters> <o:Company>Atherocenter</o:Company> <o:Lines>51</o:Lines> <o:Paragraphs>14</o:Paragraphs> <o:CharactersWithSpaces>7204</o:CharactersWithSpaces> <o:Version>11.9999</o:Version> </o:DocumentProperties> </xml><![endif]--><!--[if gte mso 9]><xml> <w:WordDocument> <w:DoNotHyphenateCaps/> <w:PunctuationKerning/> <w:UseMarginsForDrawingGridOrigin/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:Compatibility> <w:SpaceForUL/> <w:BalanceSingleByteDoubleByteWidth/> <w:DoNotLeaveBackslashAlone/> <w:ULTrailSpace/> <w:DoNotExpandShiftReturn/> <w:AdjustLineHeightInTable/> <w:SelectEntireFieldWithStartOrEnd/> <w:UseWord2002TableStyleRules/> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> </w:WordDocument> </xml><![endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState=3D"false" LatentStyleCount=3D"156"> </w:LatentStyles> </xml><![endif]--><!--[if !mso]><object classid=3D"clsid:38481807-CA0E-42D2-BF39-B33AF135CC4D" id=3Dieooui></objec= t> <style> st1\:*{behavior:url(#ieooui) } </style> <![endif]--> <style> <!-- /* Font Definitions */ @font-face {font-family:Tahoma; panose-1:2 11 6 4 3 5 4 4 2 4; mso-font-charset:204; mso-generic-font-family:swiss; mso-font-pitch:variable; mso-font-signature:1627421319 -2147483648 8 0 66047 0;} @font-face {font-family:Calibri; panose-1:2 15 5 2 2 2 4 3 2 4; mso-font-charset:204; mso-generic-font-family:swiss; mso-font-pitch:variable; mso-font-signature:-1610611985 1073750139 0 0 159 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; mso-bidi-font-size:10.0pt; font-family:"Times New Roman"; mso-fareast-font-family:Calibri; mso-fareast-language:JA;} a:link, span.MsoHyperlink {mso-style-parent:""; color:blue; text-decoration:underline; text-underline:single;} a:visited, span.MsoHyperlinkFollowed {color:purple; text-decoration:underline; text-underline:single;} p {margin-top:0cm; margin-right:0cm; margin-bottom:7.0pt; margin-left:0cm; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} address {margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; mso-bidi-font-size:10.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US; mso-fareast-language:EN-US; font-style:italic;} span.HTMLAddressChar {mso-style-name:"HTML Address Char"; mso-style-parent:""; mso-ansi-font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman"; font-style:italic;} span.name {mso-style-name:name; mso-style-parent:"";} span.contrib-degrees {mso-style-name:contrib-degrees; mso-style-parent:"";} span.collab {mso-style-name:collab; mso-style-parent:"";} /* Page Definitions */ @page {mso-page-border-surround-header:no; mso-page-border-surround-footer:no; mso-footnote-separator:url("PREDICT-rus-abst-genes-CAD-Rosenberg_files/hea= der.htm") fs; mso-footnote-continuation-separator:url("PREDICT-rus-abst-genes-CAD-Rosenb= erg_files/header.htm") fcs; mso-endnote-separator:url("PREDICT-rus-abst-genes-CAD-Rosenberg_files/head= er.htm") es; mso-endnote-continuation-separator:url("PREDICT-rus-abst-genes-CAD-Rosenbe= rg_files/header.htm") ecs;} @page Section1 {size:595.3pt 841.9pt; margin:2.0cm 42.5pt 2.0cm 3.0cm; mso-header-margin:35.4pt; mso-footer-margin:35.4pt; mso-paper-source:0;} div.Section1 {page:Section1;} /* List Definitions */ @list l0 {mso-list-id:221259930; mso-list-type:hybrid; mso-list-template-ids:-580511924 68747279 68747289 68747291 68747279 68747= 289 68747291 68747279 68747289 68747291;} @list l0:level1 {mso-level-tab-stop:36.0pt; mso-level-number-position:left; text-indent:-18.0pt;} @list l1 {mso-list-id:1060206121; mso-list-template-ids:-2084513544;} @list l1:level1 {mso-level-tab-stop:36.0pt; mso-level-number-position:left; text-indent:-18.0pt;} @list l2 {mso-list-id:2008631750; mso-list-template-ids:-333679204;} @list l2:level1 {mso-level-tab-stop:36.0pt; mso-level-number-position:left; text-indent:-18.0pt;} ol {margin-bottom:0cm;} ul {margin-bottom:0cm;} --> </style> <!--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} </style> <![endif]--> </head> <body lang=3DRU link=3Dblue vlink=3Dpurple style=3D'tab-interval:35.4pt'> <div class=3DSection1> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <b><span style=3D'font-size:20.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; mso-fareast-language:EN-US'>Многоцk= 7;нтровая валидизациn= 3; (проверка) диагностичk= 7;ской точности теста на экс= 087;рессию генов для оценки <span style=3D'color:#00000A'>&#= 1074;ыявления </span>обструктиk= 4;ной коронарной болезни<span style=3D'color:#0000= 0A'> у пациентов без диабета. </= span><o:p></o:p></span></b></p> <p class=3DMsoNormal style=3D'margin-top:7.5pt;mso-outline-level:2;backgrou= nd:white'><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;color:#403838;mso-font-kerning:18.0pt;mso-ansi-language:EN;mso-farea= st-language: EN-US;mso-bidi-font-weight:bold'>Multicenter Validation of the Diagnostic Accuracy of a Blood-Based Gene Expression Test for Assessing Obstructive Coronary Artery Disease in Nondiabetic Patients. <o:p></o:p></span></p> <p class=3DMsoNormal style=3D'background:white'><span style=3D'font-size:16= .0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;mso-fareast-langua= ge: EN-US;mso-bidi-font-weight:bold'><o:p> </o:p></span></p> <p class=3DMsoNormal><span style=3D'font-size:16.0pt;mso-bidi-font-size:10.= 0pt'>Тест, основанный на экспрессии 23 генов, позво= 083;ил предсказатn= 0; общие результаты коронарной ангиографиl= 0; (наличие или отсутствие гемодинамиm= 5;ески значимых стенозов, но &#= 1085;е их точную ло= 082;ализацию), немного превзойдя предсказанl= 0;е, основанное на клиническиm= 3; показателяm= 3; [1]. Несмотря на скромность результата, очевидно учитывая принципиалn= 0;ную новизну под = 93;ода, журнал </span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:10.0pt;mso-ansi-language:EN-US= '>TIME</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:10.0pt'> </span><= span style=3D'font-size:16.0pt;mso-bidi-font-size:10.0pt'>вкл&= #1102;чил соответствm= 1;ющую публикацию = 74; число «10 медицинскиm= 3; прорывов 2010 года» [2]<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'background:white'><span style=3D'font-size:16= .0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;mso-fareast-langua= ge: EN-US;mso-bidi-font-weight:bold'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'background:white'><span style=3D'font-size:16= .0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;mso-fareast-langua= ge: EN-US;mso-bidi-font-weight:bold'>Перево= д резюме публикации</spa= n><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareas= t-font-family: Tahoma;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-font-wei= ght: bold'> [1]</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt; mso-fareast-font-family:Tahoma;mso-fareast-language:EN-US;mso-bidi-font-wei= ght: bold'>.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <a name=3Daff-1></a><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt; mso-fareast-font-family:Tahoma;mso-fareast-language:EN-US;mso-bidi-font-wei= ght: bold'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'margin-top:6.0pt;mso-line-height-alt:12.0pt; background:white'><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt; mso-fareast-font-family:Tahoma;mso-fareast-language:EN-US;mso-bidi-font-wei= ght: bold'>«<b><span style=3D'color:#403838'>Пред&= #1087;осылки.<br> </span></b><span style=3D'color:#403838'>Диагн= ;остика обструктивl= 5;ой коронарной = 73;олезни сердца (КБС) у пациентов с риском ее во= 079;никновения может быть затруднитеl= 3;ьной и обычно требует как неинвазивнm= 9;х методов визуализацl= 0;и (получения изображениn= 3;), так и коронарной ангиографиl= 0;, являющейся золотым стандартом. </s= pan></span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>Предm= 6;ествующие исследованl= 0;я дали основание предполагаm= 0;ь, что на наличие КБС может указывать э = 82;спрессия генов периферичеl= 9;кой крови. <o:p></o:p></span></p> <p class=3DMsoNormal style=3D'margin-top:6.0pt;mso-line-height-alt:12.0pt; background:white'><b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>Цель</spa= n></b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>. <br> Подтвердитn= 0; правильнос&#= 1090;ь (действенно = 89;ть) </span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareas= t-font-family: Tahoma;color:#403838'>разрабо = 90;анного ранее,</span><span style=3D'font-size:16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838; mso-fareast-language:EN-US'> основа = 85;ного на экспрессии 23 генов, класс= 080;фикационно&= #1075;о теста</span><span style=3D'font-size:16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838'> </= span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>для диагностикl= 0; обструктивl= 5;ой коронарной болезни у пациентов без диабета. <o= :p></o:p></span></p> <p class=3DMsoNormal style=3D'margin-top:6.0pt;mso-line-height-alt:12.0pt; background:white'><b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>План, = 089;труктура.</span></b><sp= an style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'> <br> Многоцентрl= 6;вое проспективl= 5;ое испытание с пробами крови, полученнымl= 0; перед корон = 72;рной ангиографиk= 7;й. (Номер регистрациl= 0; на </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-fo= nt-size: 12.0pt;mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN; mso-fareast-language:EN-US'><a href=3D"http://ClinicalTrials.gov"><span style=3D'mso-fareast-font-family:Tahoma;color:windowtext'>ClinicalTrials</s= pan><span lang=3DRU style=3D'mso-fareast-font-family:Tahoma;color:windowtext;mso-ansi= -language: RU'>.</span><span style=3D'mso-fareast-font-family:Tahoma;color:windowtext'= >gov</span></a></span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; mso-fareast-language:EN-US'>: </span><st1:stockticker w:st=3D"on"><u><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-= font-family: Tahoma;mso-ansi-language:EN;mso-fareast-language:EN-US'>NCT</span></u></st= 1:stockticker><u><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; mso-fareast-language:EN-US'>00500617</span></u><span style=3D'font-size:16.= 0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;mso-fareast-langua= ge: EN-US'>) <span style=3D'color:#403838'><o:p></o:p></span></span></p> <p class=3DMsoNormal style=3D'margin-top:6.0pt;mso-line-height-alt:12.0pt; background:white'><b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>Местl= 6; проведения</spa= n></b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>.<br> 39 центров в Соединенныm= 3; Штатах <o:p></o:p></span></p> <p class=3DMsoNormal style=3D'margin-top:6.0pt;mso-line-height-alt:12.0pt; background:white'><b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>Пациk= 7;нты</span></b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>. <br> Независимаn= 3; валидационl= 5;ая (проверочна = 03;) когорта из 526 пациентов без диабета = 089; клиническиl= 4;и показаниямl= 0; к коронарно = 81; ангиографиl= 0;. <o:p></o:p></span></p> <p class=3DMsoNormal style=3D'margin-top:6.0pt;mso-line-height-alt:12.0pt; background:white'><b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>Измеl= 8;ения</span></b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>. <br> Анализ «рабочих характерисm= 0;ик приёмника» (РХП) (</span><span lang=3DEN-US style=3D'font-size:16.0p= t; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838; mso-ansi-language:EN-US;mso-fareast-language:EN-US'>r</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN;mso-fareast-language:EN-US'>eceiver</spa= n><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>-</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN;mso-fareast-language:EN-US'>operating</s= pan><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;color:#403838;mso-fareast-language:EN-US'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN;mso-fareast-language:EN-US'>characterist= ic</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'> [</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN;mso-fareast-language:EN-US'>ROC</span><s= pan style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>] </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN;mso-fareast-language:EN-US'>analysis</sp= an><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>) клас= 089;ификационн&= #1099;х оценок, определённm= 9;х в реальном времени с помощью полимеразнl= 6;й цепной реакции, способностn= 0; дополнить клиническиk= 7; факторы (аддитивнос = 90;ь к клиническиl= 4; факторам), ре&#= 1082;лассификац= ия вероятностl= 0; заболеваниn= 3; у пациента пациентов п = 86; отношению к статусу заболеваниn= 3;, установлен&= #1085;ому количествеl= 5;ной ангиографиk= 7;й. <br> Обструктивl= 5;ая коронарная болезнь был = 72; определена как стеноз 50% и более в одно= 081; или более крупных коронарных артериях по данным коли = 95;ественной ангиографиl= 0;.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'margin-top:6.0pt;mso-line-height-alt:12.0pt; background:white'><b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>Резуl= 3;ьтаты</span></b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>.<br> Площадь под </s= pan><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838'>кривой (ПП&#= 1050;) РХП (</span><span lang=3DEN-US style=3D'font-size:16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838; mso-ansi-language:EN-US'>ROC</span><span lang=3DEN-US style=3D'font-size:16= .0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838'> </= span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838'>кривой) была равна 0.70&plusm= n;0.02 (<i style=3D'mso-bidi-font-style:normal'>р</i>< 0.001), тест дополнил клиническиk= 7; характерис&#= 1090;ики (метод Дайамонда-Ф = 86;ррестера - </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0p= t; mso-fareast-font-family:Tahoma;color:#403838;mso-ansi-language:EN;mso-farea= st-language: EN-US'>Diamond</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.= 0pt; mso-fareast-font-family:Tahoma;color:#403838;mso-fareast-language:EN-US'>&#= 8211;</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;color:#403838;mso-ansi-language:EN;mso-fareast-language:EN-US'>Forre= ster</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>): ППК 0.72 = 089; данными теста и 0.66 без них, </span><span style=3D'font-size:16.0pt;mso-bidi-font= -size: 12.0pt;mso-fareast-font-family:Tahoma;color:#403838'>р=3D 0.003), = 080; немного доп = 86;лнил расширеннуn= 2; клиническуn= 2; модель </span><span style=3D'font-size:= 16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838; mso-fareast-language:EN-US'>(ППК 0.745 с данными теста проти = 74; 0.732 без них; р=3D 0.089).</span= ><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838'><br> Тест обеспечил лучшую реклассифиl= 2;ацию (улучшил классификаm= 4;ию) по сравнени = 02; как с методо= 084; Diamond–Forrester, так и с рk= 2;сширенной клиническоl= 1; моделью (<i style=3D'mso-bidi-fon= t-style: normal'>р</i>< 0.001).<br> </span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareas= t-font-family: Tahoma;color:#403838;mso-fareast-language:EN-US'>При пороговом числе балло = 74;, соответствm= 1;ющем 20% вероятност&= #1080; обструктивl= 6;й КБС </span><span style=3D'font-size:16.0pt;mso-bidi-font-= size: 12.0pt;mso-fareast-font-family:Tahoma;color:#403838'>(14.75), чувствителn= 0;ность и специфичноl= 9;ть были равны с= 086;ответствен&= #1085;о 85% и 43% (отрицатель = 85;ая предсказатk= 7;льная ценность 83% и положительl= 5;ая предсказатk= 7;льная ценность 46%). У</spa= n><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareas= t-font-family: Tahoma;color:#403838;mso-ansi-language:EN-US'> 33% </span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838'>пациенто = 74;</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN-US'> </span><span style=3D'font-size:16.= 0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838'>= 095;исло</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN-US'> </span><span style=3D'font-size:16.= 0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838'>= 073;аллов</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN-US'> </span><span style=3D'font-size:16.= 0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838'>= 073;ыло</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN-US'> </span><span style=3D'font-size:16.= 0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838'>= 085;иже</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN-US'> </span><span style=3D'font-size:16.= 0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838'>= 101;того</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN-US'> </span><span style=3D'font-size:16.= 0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838'>= 087;орога</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareas= t-font-family: Tahoma;color:#403838;mso-ansi-language:EN-US'>.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'margin-top:6.0pt;mso-line-height-alt:12.0pt; background:white'><b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>Ограl= 5;ичение.<br> </span></b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fa= reast-font-family: Tahoma;color:#403838;mso-fareast-language:EN-US'>Былl= 0; исключены пациенты с хроническиl= 4;и воспалителn= 0;ными заболеваниn= 3;ми, повышеннымl= 0; уровнями лейкоцитов или сердечн = 99;х белковых маркеров, ил= 080; с диабетом. <o:p></o:= p></span></p> <p class=3DMsoNormal style=3D'margin-top:6.0pt;mso-line-height-alt:12.0pt; background:white'><b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>Заклn= 2;чение</span></b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>.</span><span style=3D'font-size:= 16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838'><br> </span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareas= t-font-family: Tahoma;color:#403838;mso-fareast-language:EN-US'>Неиl= 5;вазивный тест, в котором используетl= 9;я цельная кровь крови, основанный на экспресс = 80;и генов и демографичk= 7;ских характерисm= 0;иках, может быть полезным дл = 03; оценки обструктивl= 5;ой КБС<span style=3D'mso-spacerun:yes'>  </span>у больных без диабета без известной КБС».<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-b= idi-font-size: 12.0pt;mso-fareast-font-family:Tahoma;color:#403838;mso-fareast-language:EN= -US'><o:p> </o:p></span></b></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-b= idi-font-size: 12.0pt;mso-fareast-font-family:Tahoma;color:#403838;mso-fareast-language:EN= -US'>Некоторые положения раздела обсуждение = 87;убликации </span></b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fa= reast-font-family: Tahoma;color:#403838;mso-fareast-language:EN-US'>[1]<b style=3D'mso-bidi-fo= nt-weight: normal'>.<o:p></o:p></b></span></p> <p class=3DMsoNormal><span style=3D'font-size:16.0pt;mso-bidi-font-size:10.= 0pt'>Наш алгоритм экспрессии генов может иметь клиническиk= 7; преимущестk= 4;а над применя = 77;мыми в настоящее время неинвазивнm= 9;ми диагностичk= 7;скими методами, та= 082; как для него нужна тольк = 86; стандартнаn= 3; проба крови = 080; он не требуе= 090; облучения, внутривеннl= 6;го введения контрастныm= 3; агентов, или физиологичk= 7;ских или фармакологl= 0;ческих стрессоров. = 042; проверочноl= 1; когорте, например, только у 37% пациентов, у которых был = 72; выполнена инвазивная ангиографиn= 3;, обнаружено обструктивl= 5;ое поражение коронарных артерий, его частота был = 72; особенно низкой у женщин (26%). <o:p></o:p></span></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-b= idi-font-size: 12.0pt;mso-fareast-font-family:Tahoma;color:#403838;mso-fareast-language:EN= -US'><o:p> </o:p></span></b></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:18.0pt;mso-b= idi-font-size: 12.0pt;mso-fareast-font-family:Tahoma;color:#403838;mso-fareast-language:EN= -US'>Комментари= й редакторов журнала Анналы Внутренней медицины </span></b><span style=3D'font-size:18.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>[1]<b style=3D'mso-bidi-font-weig= ht: normal'>. <o:p></o:p></b></span></p> <p class=3DMsoNormal style=3D'mso-layout-grid-align:none;text-autospace:non= e'><b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :"Times New Roman"; mso-fareast-language:RU'>«Контек&= #1089;т <br> </span></b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fa= reast-font-family: "Times New Roman";mso-fareast-language:RU;mso-bidi-font-weight:bold'>Т= ;ребуются лучшие методы выяв = 83;ения среди пацие = 85;тов с болью в грудной клетке (в груди) тех, у кого имеетс = 03; клинически важная (знач= 080;мая) коронарную болезнь <o:p></o:p></span></p> <p class=3DMsoNormal style=3D'mso-layout-grid-align:none;text-autospace:non= e'><b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :"Times New Roman"; mso-fareast-language:RU'>Вклад настоящего исследованl= 0;я.<br> </span></b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fa= reast-font-family: "Times New Roman";mso-fareast-language:RU;mso-bidi-font-weight:bold'>Э= ;то исследованl= 0;е обнаружило умеренное (</span><sp= an lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareas= t-font-family: "Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:RU;mso-bidi-= font-weight: bold'>modest</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-fo= nt-size: 12.0pt;mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU; mso-bidi-font-weight:bold'> </span><span style=3D'font-size:16.0pt;mso-bidi= -font-size: 12.0pt;mso-fareast-font-family:"Times New Roman";mso-fareast-language:RU; mso-bidi-font-weight:bold'>– скромное) ул= 091;чшение предсказанl= 0;я наличия заболеваниn= 3; коронарных артерий при использоваl= 5;ии генного теста по сравнению с клиническиl= 4;и оценками (метод </span><span lang=3DEN-US style=3D'fon= t-size: 16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-US;mso-fareast-language:RU'>Diamond</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :"Times New Roman"; mso-fareast-language:RU'>–</span><span lang=3DEN-US style=3D'font-siz= e:16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:"Times New Roman";mso-ans= i-language: EN-US;mso-fareast-language:RU'>Forrester</span><span style=3D'font-size:16.= 0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:"Times New Roman";mso-far= east-language: RU'>), это улучшение о = 82;азалось менее выраженным при сравнен = 80;и с расширенныl= 4; набором клиническиm= 3; показателе&#= 1081;. <b><span style=3D'mso-spacerun:yes'> </span><o:p></o:p></b></span></p> <p class=3DMsoNormal style=3D'mso-layout-grid-align:none;text-autospace:non= e'><b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :"Times New Roman"; mso-fareast-language:RU'>Основан&= #1080;я для осторожносm= 0;и в интерпрет = 72;ции<br> </span></b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fa= reast-font-family: "Times New Roman";mso-fareast-language:RU'>Сред = 80; включённых = 74; исследованl= 0;е пациентов была относительl= 5;о высокой рас = 87;ространенн&#= 1086;сть заболеваниn= 3; коронарных артерий. Из исследованl= 0;я исключены пациенты </span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>с хро = 85;ическими воспалителn= 0;ными расстройстk= 4;ами, повышенным = 82;оличеством лейкоцитов или уровней = 089;ердечных белковых маркеров, а также больн = 77; диабетом</span><b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :"Times New Roman"; mso-fareast-language:RU'><o:p></o:p></span></b></p> <p class=3DMsoNormal style=3D'mso-layout-grid-align:none;text-autospace:non= e'><b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :"Times New Roman"; mso-fareast-language:RU'>Вывод (импликация) <o= :p></o:p></span></b></p> <p class=3DMsoNormal style=3D'mso-layout-grid-align:none;text-autospace:non= e'><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :"Times New Roman"; mso-fareast-language:RU'>Требует&= #1089;я дальнейшее исследованl= 0;е для оценки значения генного теста для точного пре = 76;сказания наличия заболеваниn= 3; коронарных артерий».<span style=3D'mso-spacerun:yes'>  </span><o:p></o:p></span></p> <p class=3DMsoNormal style=3D'mso-layout-grid-align:none;text-autospace:non= e'><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :"Times New Roman"; mso-fareast-language:RU'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-b= idi-font-size: 12.0pt;mso-fareast-font-family:Tahoma;color:#403838;mso-fareast-language:EN= -US'>Комментари= й </span></b><b style=3D'mso-bidi-font-weight:normal'><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN-US;mso-fareast-language:EN-US'>E</span><= /b><b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-b= idi-font-size: 12.0pt;mso-fareast-font-family:Tahoma;color:#403838;mso-fareast-language:EN= -US'>.</span></b><b style=3D'mso-bidi-font-weight:normal'><span lang=3DEN-US style=3D'font-size= :16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;color:#403838; mso-ansi-language:EN-US;mso-fareast-language:EN-US'>Topol</span></b><b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-b= idi-font-size: 12.0pt;mso-fareast-font-family:Tahoma;color:#403838;mso-fareast-language:EN= -US'> [3]<o:p></o:p></span></b></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>Я считаю, что основная функция нового тест = 72;, значение которого мы подтвердилl= 0; (валидизиро = 74;али), – со времене= 084; его исследованl= 0;й станет больше - в том, что он позволит избавиться от ненужных (не обусловленl= 5;ых необходимоl= 9;тью) ангиограмм. <o:= p></o:p></span></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-b= idi-font-size: 12.0pt'>Дополнени = 77; из статьи на интернет сайте </span></b><b style=3D'mso-bidi-font-we= ight: normal'><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.= 0pt; mso-ansi-language:EN-US'>Medscape</span></b><b style=3D'mso-bidi-font-weigh= t: normal'><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.= 0pt'> </span></b><b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-b= idi-font-size: 12.0pt'>[3] <o:p></o:p></span></b></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt'>Тес&= #1090; создавался = 74; 3 фазы. Гены, отражающие = 85;аличие обструктивl= 5;ой коронарной болезни был = 80; идентифициl= 8;ованы на 200 пациентах без диабета. Технология количествеl= 5;ной полимеразнl= 6;й цепной реакции в ре= 072;льном времени был = 72; использоваl= 5;а для дальней = 96;ей оценки и сов= 077;ршенствова&= #1085;ия набора гено = 74;, и пробы кров= 080; от 600 пациентов б = 99;ли использоваl= 5;ы для вывода алгоритма, о= 073;ъединяющег&= #1086; уровни экспрессии 23 генов и друг= 080;е характерисm= 0;ики пациентов. И этот алгоритм бы = 83; проверен (валидизиро = 74;ан) в проспективl= 5;ом многоцентрl= 6;вом клиническоl= 4; испытании </span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-ansi-l= anguage: EN-US'>PREDICT</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.= 0pt'> (</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.= 0pt; mso-ansi-language:EN-US'>the</span><span lang=3DEN-US style=3D'font-size:16= .0pt; mso-bidi-font-size:12.0pt'> </span><span lang=3DEN-US style=3D'font-size:16= .0pt; mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>Personalized</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt'> </span><= span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-ansi-l= anguage: EN-US'>Risk</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-fon= t-size: 12.0pt'> </span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-= size: 12.0pt;mso-ansi-language:EN-US'>Evaluation</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt'> </span><span lang=3DE= N-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US= '>and</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt'> </span><= span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-ansi-l= anguage: EN-US'>Diagnosis</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bid= i-font-size: 12.0pt'> </span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-= size: 12.0pt;mso-ansi-language:EN-US'>In</span><span lang=3DEN-US style=3D'font-s= ize: 16.0pt;mso-bidi-font-size:12.0pt'> </span><span lang=3DEN-US style=3D'font-= size: 16.0pt;mso-bidi-font-size:12.0pt;mso-ansi-language:EN-US'>the</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt'> </span><= span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-ansi-l= anguage: EN-US'>Coronary</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi= -font-size: 12.0pt'> </span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-= size: 12.0pt;mso-ansi-language:EN-US'>Tree</span><span style=3D'font-size:16.0pt; mso-bidi-font-size:12.0pt'> - персонализl= 0;рованная оценка риск = 72; и диагноз в коронарном сосудистом русле) <o:p></o:p></span></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-b= idi-font-size: 12.0pt;mso-fareast-font-family:Tahoma;color:#403838;mso-fareast-language:EN= -US'><o:p> </o:p></span></b></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <b style=3D'mso-bidi-font-weight:normal'><span style=3D'font-size:16.0pt;mso-b= idi-font-size: 12.0pt;mso-fareast-font-family:Tahoma;color:#403838;mso-fareast-language:EN= -US'>Источники</span>= </b><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>.<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'margin-top:6.0pt;margin-right:0cm;margin-bott= om:0cm; margin-left:21.25pt;margin-bottom:.0001pt;text-indent:-21.25pt;mso-line-hei= ght-alt: 12.0pt;mso-list:l0 level1 lfo3;tab-stops:list 21.3pt;background:white'><![i= f !supportLists]><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :"Times New Roman"; color:#403838;mso-fareast-language:EN-US'><span style=3D'mso-list:Ignore'>1= .<span style=3D'font:7.0pt "Times New Roman"'>      </spa= n></span></span><![endif]><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>Rosenberg</span><span lang=3DEN style=3D'font-= size: 16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><s= pan lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>S</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; mso-ansi-language:EN'>Elashoff</span><span lang=3DEN style=3D'font-size:16.= 0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>M</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>.</span><span lang=3DEN style=3D'fon= t-size: 16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;mso-ansi-la= nguage: EN'>R</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-f= areast-font-family: Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-s= ize: 12.0pt;mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>Beineke</span><= span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-siz= e:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>P</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>Daniels</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-siz= e:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>S</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'>.</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>E</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; mso-ansi-language:EN'>Wingrove</span><span lang=3DEN style=3D'font-size:16.= 0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>J</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>.</span><span lang=3DEN style=3D'fon= t-size: 16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;mso-ansi-la= nguage: EN'>A</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-f= areast-font-family: Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-s= ize: 12.0pt;mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>Tingley</span><= span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-siz= e:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>W</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'>.</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>G</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; mso-ansi-language:EN'>Sager</span><span lang=3DEN style=3D'font-size:16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>P</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>.</span><span lang=3DEN style=3D'fon= t-size: 16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;mso-ansi-la= nguage: EN'>T</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-f= areast-font-family: Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-s= ize: 12.0pt;mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>Sehnert</span><= span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-siz= e:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>A</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'>.</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>J</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; mso-ansi-language:EN'>Yau</span><span lang=3DEN style=3D'font-size:16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>M</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; mso-ansi-language:EN'>Kraus</span><span lang=3DEN style=3D'font-size:16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>W</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>.</span><span lang=3DEN style=3D'fon= t-size: 16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;mso-ansi-la= nguage: EN'>E</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-f= areast-font-family: Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-s= ize: 12.0pt;mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>Newby</span><sp= an lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-siz= e:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>L</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'>. </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>K</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>Schwartz</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-siz= e:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>R</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'>.</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>S</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; mso-ansi-language:EN'>Voros</span><span lang=3DEN style=3D'font-size:16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>S</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; mso-ansi-language:EN'>Ellis</span><span lang=3DEN style=3D'font-size:16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>S</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>.</span><span lang=3DEN style=3D'fon= t-size: 16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;mso-ansi-la= nguage: EN'>G</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-f= areast-font-family: Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-s= ize: 12.0pt;mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>Tahirkheli</spa= n><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-siz= e:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>N</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>Waksman</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-siz= e:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>R</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>McPherson</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-siz= e:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>J</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>Lansky</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-siz= e:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>A</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>Winn</span><span lang= =3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>M</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'>.</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>E</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; mso-ansi-language:EN'>Schork</span><span lang=3DEN style=3D'font-size:16.0p= t; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>N</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>.</span><span lang=3DEN style=3D'fon= t-size: 16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma;mso-ansi-la= nguage: EN'>J</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-f= areast-font-family: Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-s= ize: 12.0pt;mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>Topol</span><sp= an lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-siz= e:12.0pt; mso-fareast-font-family:Tahoma;mso-ansi-language:EN'>E</span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma'>.</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>J</span><span style=3D'font-size:16.0pt;mso-bi= di-font-size: 12.0pt;mso-fareast-font-family:Tahoma'>., </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; mso-ansi-language:EN'>and</span><span lang=3DEN style=3D'font-size:16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>for</span><span lang=3DEN style=3D'font-size:1= 6.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>the</span><span lang=3DEN style=3D'font-size:1= 6.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>PREDICT</span><span style=3D'font-size:16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> (</span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>Personalized</span><span lang=3DEN style=3D'fo= nt-size: 16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><s= pan lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>Risk</span><span lang=3DEN style=3D'font-size:= 16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>Evaluation</span><span lang=3DEN style=3D'font= -size: 16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><s= pan lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>and</span><span lang=3DEN style=3D'font-size:1= 6.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>Diagnosis</span><span lang=3DEN style=3D'font-= size: 16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><s= pan lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>in</span><span lang=3DEN style=3D'font-size:16= .0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>the</span><span lang=3DEN style=3D'font-size:1= 6.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>Coronary</span><span lang=3DEN style=3D'font-s= ize: 16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'> </span><s= pan lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>Tree</span><span style=3D'font-size:16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'>) </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;mso-ansi-language:EN'>Investigators</span><span style=3D'font-size:1= 6.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:Tahoma'>*. </span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareas= t-font-family: Tahoma;color:#403838;mso-ansi-language:EN-US'>Multicenter Validation of the Diagnostic Accuracy of a Blood-Based Gene Expression Test for Assessing Obstructive Coronary Artery Disease in Nondiabetic Patients. </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;color:#403838;mso-ansi-language:EN;mso-fareast-language:EN-US'>Ann</= span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;color:#403838;mso-fareast-language:EN-US'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN;mso-fareast-language:EN-US'>Intern</span= ><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-f= ont-family: Tahoma;color:#403838;mso-fareast-language:EN-US'> </span><span lang=3DEN style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN;mso-fareast-language:EN-US'>Med</span><s= pan style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'>. 2010; 153: 425-434</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareas= t-font-family: Tahoma;color:#403838;mso-ansi-language:EN-US;mso-fareast-language:EN-US'>.<= /span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'><o:p></o:p></span></p> <p class=3DMsoNormal style=3D'margin-top:6.0pt;margin-right:0cm;margin-bott= om:0cm; margin-left:21.25pt;margin-bottom:.0001pt;text-indent:-21.25pt;mso-list:l0 = level1 lfo3; tab-stops:list 21.3pt;mso-layout-grid-align:none;text-autospace:none'><![if= !supportLists]><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareas= t-font-family: "Times New Roman";color:#403838;mso-ansi-language:EN-US;mso-fareast-languag= e: EN-US'><span style=3D'mso-list:Ignore'>2.<span style=3D'font:7.0pt "Times N= ew Roman"'>      </span></span></span><![endif]><span lang=3DEN-US style=3D'font-size:16.0pt; mso-bidi-font-size:12.0pt;mso-fareast-font-family:"Times New Roman";color:b= lack; mso-ansi-language:EN-US;mso-fareast-language:RU'>Park A. The top 10 everyth= ing of 2010: Top 10 medical<span style=3D'mso-spacerun:yes'>  </span>breakthroughs. No. 7. Blood test for heart attack. </span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :"Times New Roman"; color:black;mso-fareast-language:RU'>Time.</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :"Times New Roman"; color:black;mso-ansi-language:EN-US;mso-fareast-language:RU'> December 9, 2= 010. Available at: </span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-= font-size: 12.0pt;mso-fareast-font-family:"Times New Roman";color:#004277;mso-ansi-lan= guage: EN-US;mso-fareast-language:RU'>http://www.time.com</span><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-ansi-language:EN-US;mso-fareast-language:EN-US'><o:p></o:= p></span></p> <p class=3DMsoNormal style=3D'margin-top:6.0pt;margin-right:0cm;margin-bott= om:0cm; margin-left:21.25pt;margin-bottom:.0001pt;text-indent:-21.25pt;mso-outline-= level: 2;mso-list:l0 level1 lfo3;tab-stops:list 21.3pt;background:white'><![if !su= pportLists]><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareas= t-font-family: "Times New Roman";mso-ansi-language:EN-US'><span style=3D'mso-list:Ignore'>= 3.<span style=3D'font:7.0pt "Times New Roman"'>      </spa= n></span></span><![endif]><span lang=3DEN-US style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-ansi-l= anguage: EN-US'>Brookes L.<span style=3D'mso-font-kerning:18.0pt'> A Genetic Test to= End Angiography? </span>Best Evidence Interview With Eric Topol. http://www.medscape.com/. Posted: 01/21/2011<o:p></o:p></span></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'mso-line-height-alt:12.0pt;background:white'>= <span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'><o:p> </o:p></span></p> <p class=3DMsoNormal style=3D'line-height:12.0pt;background:white'><span style=3D'color:#393939'>Подгото&#= 1074;лено Н.А.Грацианс= 082;им<br> Размещено 31/01/2011<= /span><span style=3D'font-size:16.0pt;mso-bidi-font-size:12.0pt;mso-fareast-font-family= :Tahoma; color:#403838;mso-fareast-language:EN-US'><o:p></o:p></span></p> </div> </body> </html> ------=_NextPart_01CBC1AC.50696050 Content-Location: file:///C:/9112A2A7/PREDICT-rus-abst-genes-CAD-Rosenberg_files/header.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:w=3D"urn:schemas-microsoft-com:office:word" xmlns:st1=3D"urn:schemas-microsoft-com:office:smarttags" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dus-ascii"> <meta name=3DProgId content=3DWord.Document> <meta name=3DGenerator content=3D"Microsoft Word 11"> <meta name=3DOriginator content=3D"Microsoft Word 11"> <link id=3DMain-File rel=3DMain-File href=3D"../PREDICT-rus-abst-genes-CAD-Rosenberg.htm"> <![if IE]> <base href=3D"file:///C:\9112A2A7\PREDICT-rus-abst-genes-CAD-Rosenberg_files\head= er.htm" id=3D"webarch_temp_base_tag"> <![endif]><o:SmartTagType namespaceuri=3D"urn:schemas-microsoft-com:office:smarttags" name=3D"stockt= icker"/> </head> <body lang=3DRU link=3Dblue vlink=3Dpurple> <div style=3D'mso-element:footnote-separator' id=3Dfs> <p class=3DMsoNormal><span style=3D'mso-special-character:footnote-separato= r'><![if !supportFootnotes]> <hr align=3Dleft size=3D1 width=3D"33%"> <![endif]></span></p> </div> <div style=3D'mso-element:footnote-continuation-separator' id=3Dfcs> <p class=3DMsoNormal><span style=3D'mso-special-character:footnote-continua= tion-separator'><![if !supportFootnotes]> <hr align=3Dleft size=3D1> <![endif]></span></p> </div> <div style=3D'mso-element:endnote-separator' id=3Des> <p class=3DMsoNormal><span style=3D'mso-special-character:footnote-separato= r'><![if !supportFootnotes]> <hr align=3Dleft size=3D1 width=3D"33%"> <![endif]></span></p> </div> <div style=3D'mso-element:endnote-continuation-separator' id=3Decs> <p class=3DMsoNormal><span style=3D'mso-special-character:footnote-continua= tion-separator'><![if !supportFootnotes]> <hr align=3Dleft size=3D1> <![endif]></span></p> </div> </body> </html> ------=_NextPart_01CBC1AC.50696050 Content-Location: file:///C:/9112A2A7/PREDICT-rus-abst-genes-CAD-Rosenberg_files/filelist.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" <xml xmlns:o=3D"urn:schemas-microsoft-com:office:office"> <o:MainFile HRef=3D"../PREDICT-rus-abst-genes-CAD-Rosenberg.htm"/> <o:File HRef=3D"header.htm"/> <o:File HRef=3D"filelist.xml"/> </xml> ------=_NextPart_01CBC1AC.50696050--