ÿþ <HTML> <HEAD> <TITLE> 5:><5=40F88 AHA ?> ?@>D8;0:B8:5 A5@45G=>-A>AC48ABKE 701>;520=89 C 65=I8= - Athero.ru</TITLE> <META NAME="keywords" CONTENT="0B5@>A:;5@>7, :>@>=0@=0O 1>;57=L A5@4F0, D0:B>@K @8A:0, ?@>D8;0:B8:0, 38?>;8?845<8G5A:0O B5@0?8O, :0@48>;>38O"> <link rel=stylesheet href="athero.css" type="text/css"> </head> <BODY BGCOLOR="#ffffff" link=#993366 vlink=#993366 alink=#993366 topmargin=0 leftmargin=0> <table cellspacing=0 cellpadding=0 border=0 width=760> <tr><td width=230 valign=top><iframe width=220 height=1800 frameborder=0 vspace=0 hspace=0 marginwidth=0 marginheight=0 scrolling=no src="nav_root.htm"></iframe> </td><td valign=top><img src="http://counter.rambler.ru/top100.cnt?352447" alt="" width=1 height=1 border=0 align=right> <h3> 5:><5=40F88 ?> ?@>D8;0:B8:5 A5@45G=>-A>AC48ABKE 701>;520=89 C 65=I8=, >A=>20==K5 =0 4>:070==>< </h3> <p><b>AHA Scientific Statement. Evidence-Based Guidelines for Cardiovascular Disease Prevention in Women. Circulation 2004; 109: 672-693</b></p> <dd>>43>B>2;5=> ..>1>@4638=8475 8 ..@0F80=A:8<. ?C1;8:>20=> 2 6C@=0;5 "0@48>;>38O", B.4, 2004</dd> <p align=justify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A2O78 A MB8< ?>O28;0AL 1070 4;O A>740=8O >A=>20==KE =0 4>:070==>< @5:><5=40F89 ?> ?@54C?@5645=8N ! 8 55 >A;>6=5=89, A?5F8D8G5A:8 >B=>AOI8EAO : 65=I8=0<. <5==> B0:85 @5:><5=40F88 1K;8 ?>43>B>2;5=K M:A?5@B0<8 <5@8:0=A:>9 AA>F80F88 !5@4F0 (!) . 4=0:> 40==KE, ?>;CG5==KE 8<5==> C 65=I8=, 4;O >1>A=>20=8O 2A5E @5:><5=40F89 2A5 65 =54>AB0B>G=>, 8 G0AB> >=8 2A5 5I5 1078@CNBAO =0 @57C;LB0B0E, ?>;CG5==KE ?@58<CI5AB25==> C <C6G8=. @><5 B>3>, E0@0:B5@8AB8:8 «@50;L=KE» 65=I8=, B.5 B5E, :B> >1KG=> 2AB@5G05BAO 2> 2@0G51=>9 ?@0:B8:5, 2> <=>3>< >B;8G0NBAO >B E0@0:B5@8AB8: :>=B8=35=B0 @0=4><878@>20==KE 8AA;54>20=89. >MB><C 2 4>:C<5=B5 !, >A=>2=K5 ?>;>65=8O :>B>@>3> ?@82545=K =865, 8A?>;L7C5BAO ?>=OB85 «8=45:A @0A?@>AB@0=5=8O 40==KE =0 65=I8=» (>B=>H5=8O 8E : 65=I8=0<). -B>B 8=45:A :>;8G5AB25==> E0@0:B5@87C5B =0A:>;L:> D0:BK, =0 :>B>@KE >A=>20=0 @5:><5=40F8O, 8<5NB >B=>H5=85 : ?@54C?@5645=8N ! 8<5==> C 65=I8=. <p align=justify>!>3;0A=> 70O2;5=8N 02B>@>2, F5;L MB>3> :>;;5:B82=>3> B@C40 - A>740BL ?5@2K9 >A=>20==K9 =0 4>:070==>< =01>@ @5:><5=40F89 ?> ?@>D8;0:B8:5 ?@54C?@5645=8N ! C 27@>A;KE 65=I8= (20 ;5B 8 AB0@H5) A H8@>:8< 480?07>=>< A5@45G=>A>AC48AB>3> @8A:0. <p align=justify>A=>2=K5 ?>;>65=8O 4>:C<5=B0 ?@54AB02;5=K 2 A>45@60I8EAO 2 =5< B01;8F0E, ?5@52>4 :>B>@KE ?@54AB02;5= =865. <p><i>"01;8F0. 1. !?5:B@ A5@45G=>-A>AC48AB>3> @8A:0 C 65=I8=</i></p> <table cellspacing=0 border=1 cellpadding=3> <tr><td>%0@0:B5@8AB8:0 @8A:0</td><td> 1A>;NB=K9 @8A: ! 70 10 ;5B</td><td> ;8=8G5A:85 ?@8<5@K</td></tr> <tr><td>KA>:89</td><td> >20%</td><td> /2=0O ! <br>-:2820;5=BK !, B0:85 :0: F5@51@>20A:C;O@=>5 701>;520=85*, 701>;520=85 ?5@8D5@8G5A:8E 0@B5@89, 0=52@87<0 1@NH=>9 0>@BK, 48015B, E@>=8G5A:>5 701>;520=85 ?>G5:**. </td></tr> <tr><td>@><56CB>G=K9</td><td> 10-20%</td><td> <br>!C1:;8=8G5A:0O ! + (=0?@8<5@, :0;LF8D8:0F8O :>@>=0@=KE 0@B5@89). <br>5B01>;8G5A:89 A8=4@><. <br>=>65AB25==K5 D0:B>@K @8A:0 ++. <br>K@065==>5 ?>2KH5=85 C@>2=O >4=>3> D0:B>@0 @8A:0 § . <br> >4AB25==8:(8) ?5@2>9 AB5?5=8 A @0=> 2>7=8:H8< (2 2>7@0AB5 4> 55 ;5B 4;O <C6G8=, 4> 65 ;5B  4;O 65=I8=) 0B5@>A:;5@>B8G5A:8< A5@45G=>-A>AC48ABK< 701>;520=85<.</td></tr> <tr><td>87:89</td><td> &lt;10%</td><td> >65B 2:;NG0BL 65=I8= A =5A:>;L:8<8 D0:B>@0<8 @8A:0, <5B01>;8G5A:8< A8=4@><><, A >4=8< D0:B>@>< @8A:0 8;8 157 D0:B>@>2 @8A:0. <tr><td>?B8<0;L=K9</td><td> &lt;10%</td><td> ?B8<0;L=K9 C@>25=L D0:B>@>2 @8A:0 8 74>@>2K9 >1@07 687=8.</td></tr> </table> <dd>@8<5G0=8O. <br>* - &5@51@>20A:C;O@=>5 701>;520=85 <>65B 1KBL =5 A2O70==K< A 2KA>:8< @8A:>< !, 5A;8 ?>@065=K A>AC4K 2KH5 A>==KE 0@B5@89. @8 AC65=8OE A>==KE 0@B5@89 >50% (A>?@>2>640NI85AO A8<?B><0<8 8;8 15AA8<?B><=K5) @8A: ! 2KA>:89. <br>** - > <5@5 CEC4H5=8O E@>=8G5A:>3> 701>;520=8O ?>G5: 8 53> ?@>3@5AA8@>20=8O : B5@<8=0;L=><C AB0488 @8A: ! ACI5AB25==> 2>7@0AB05B. <br>+ - # =5:>B>@KE 1>;L=KE A AC1:;8=8G5A:8< A5@45G=>A>AC48ABK< 701>;520=85< 10-;5B=89 @8A: ! >:07K205BA 2KH5 20%, 8 >=8 4>;6=K 1KBL ?5@52545=K 2 :0B53>@8N 2KA>:>3> @8A:0. <br>++ - 5=I8=K A <=>65AB25==K<8 D0:B>@0<8 @8A:0 <>3CB ?>?0ABL 2 ;N1CN 87 B@5E :0B53>@89 @8A:0. <br>§ - # 1>;LH8=AB20 65=I8= A >4=8< BO65;K< D0:B>@>< @8A:0 10-;5B=89 @8A: >:07K205BAO <10%. <dd> <p><i>"01;8F0 2. ;0AA8D8:0F8O 8 AB5?5=L C1548B5;L=>AB8 (4>:070==>AB8)</i></p> <table cellspacing=0 border=1 cellpadding=3> <tr><td>&nbsp;</td><td> >I=>ABL @5:><5=40F89</td></tr> <tr><th colspan=2>;0AA8D8:0F8O</td></tr> <tr><td>;0AA I</td><td> <5H0B5;LAB2> ?>;57=> 8 MDD5:B82=></td></tr> <tr><td>;0AA IIa</td><td> !>2>:C?=>ABL 40==KE 8AA;54>20=89 8 <=5=8O M:A?5@B>2 A:;>=ONBAO 2 AB>@>=C ?>;57=>AB8 8 MDD5:B82=>AB8 2<5H0B5;LAB20.</td></tr> <tr><td>;0AA IIb</td><td> > 8<5NI8<AO 40==K< 8 <=5=8N M:A?5@B>2 ?>;57=>ABL 8 MDD5:B82=>ABL 2<5H0B5;LAB20 CAB0=>2;5=K 2 <5=LH59 AB5?5=8 (<5=55 >G5284=K).</td></tr> <tr><td>;0AA III</td><td> <5H0B5;LAB2> =5 ?>;57=>, =5 MDD5:B82=>, 8 <>65B >:070BLAO 2@54=K<.</td></tr> <tr><th colspan=2>#@>25=L 4>:070==>AB8</td></tr> <tr><td>A</td><td> >AB0B>G=>5 :>;8G5AB2> 40==KE, ?>;CG5==KE 2> <=>38E @0=4><878@>20==KE 8AA;54>20=8OE.</td></tr> <tr><td>B</td><td> 3@0=8G5==>5 :>;8G5AB2> 40==KE 8;8 87 >4=>3> @0=4><878@>20==>3> 8AA;54>20=8O, 8;8 5I5 8 4@C38E =5@0=4><878@>20==KE 8AA;54>20=89.</td></tr> <tr><td>C</td><td> A=>2K20=> =0 <=5=88 M:A?5@B>2, >?8A0=89 A;CG052 (case studies) 8;8 =0 ?@8=OBKE AB0=40@B0E ;5G5=8O.</td></tr> <tr><th colspan=2>!B5?5=L >1>1I5=8O (@0A?@>AB@0=5=8O 40==KE =0 65=I8=)</td></tr> <tr><td>1</td><td> ?>;=5 25@>OB=>, GB> @57C;LB0BK @0A?@>AB@0=ONBAO =0 65=I8=.</td></tr> <tr><td>2</td><td>  >?@545;5==>9 AB5?5=8 @57C;LB0BK @0A?@>AB@0=ONBAO =0 65=I8=.</td></tr> <tr><td>3</td><td> 0;> 25@>OB=>, GB> @57C;LB0BK @0A?@>AB@0=ONBAO =0 65=I8=.</td></tr> <tr><td>0</td><td> 52>7<>6=> >?@545;8BL, @0A?@>AB@0=O5BAO ;8 @57C;LB0BK =0 65=I8=.</td></tr> </table> <p align=center><u><b>>48D8:0F8O >1@070 687=8 <br><5H0B5;LAB20 2 >1@07 687=8</b></u></p> <p><b>C@5=85</b></p> <p align=justify>!;54C5B ?>AB>O==> ?>>I@OBL 65=I8= =5 :C@8BL 8 871530BL ?0AA82=>3> :C@5=8O (:;0AA I, C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -1. <p><b>$878G5A:0O 0:B82=>ABL</b></p> <p align=justify> 5:><5=4C5BAO <8=8<C< 30 <8=CB (AC<<0@=> 70 45=L) D878G5A:>9 0:B82=>AB8 («=0:0?;820BL 30 <8=CB 2 B5G5=85 4=O») C<5@5==>9 8=B5=A82=>AB8 (=0?@8<5@, 1KAB@0O E>4L10). 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(;0AA IIa, C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -2. <p><b><530 3 68@=K5 :8A;>BK</b></p> <p align=justify># 65=I8= A 2KA>:8< @8A:><* <>6=> @0AA<>B@5BL ?@8<5=5=85 ><530 3 68@=KE :8A;>B 2 :0G5AB25 4>?>;=5=8O : 485B5 (;0AA IIb, C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -2. <p><b>$>;8520O :8A;>B0</b></p> <p align=justify> A;CG05 >1=0@C65=8O C@>2=O 3><>F8AB58=0, ?@52KH0NI53> =>@<C, C 65=I8= A 2KA>:8< @8A:><* (70 8A:;NG5=85< ?5@8>40 ?>A;5 ?@>F54C@ @520A:C;O@870F88) 2 :0G5AB25 4>?>;=5=8O : 485B5 <>6=> @0AA<>B@5BL ?@8<5=5=85 D>;852>9 :8A;>BK (;0AA IIb, C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -2. <p align=center><u><b>>7459AB285 (2<5H0B5;LAB2>) =0 >A=>2=K5 D0:B>@K @8A:0</u></b></p> <p align=justify>@B5@80;L=>5 402;5=85 (0@B5@80;L=0O 38?5@B>=8O)  >1@07 687=8 <p align=justify>!B@5<8BLAO : 4>AB865=8N >?B8<0;L=>3> C@>2=O 0@B5@80;L=>3> 402;5=8O <120/80 <<. @B. AB. A ?><>ILN 87<5=5=8O >1@070 687=8. (;0AA I, C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -1. <p><b>@B5@80;L=>5 402;5=85 (0@B5@80;L=0O 38?5@B>=8O)  ;5:0@AB20</b></p> <p align=justify>$0@<0:>B5@0?8O ?>:070=0, 5A;8 0@B5@80;L=>5 402;5=85 e"140/90 <<. @B. AB.; 8;8 ?@8 <5=LH5< 7=0G5=88 0@B5@80;L=>3> 402;5=8O 2 A;CG05 =0;8G8O A2O70==KE A C@>2=5< 402;5=8O :@>28 ?>@065=89 >@30=>2 <8H5=59, ;81> A0E0@=>3> 48015B0. "80784=K5 48C@5B8:8 4>;6=K 1KBL :><?>=5=B>< <548:0<5=B>7=>9 B5@0?88 C 1>;LH8=AB20 1>;L=KE, 70 8A:;NG5=85< A;CG052, :>340 >=8 ?@>B82>?>:070=K. (;0AA I, #@>25=L 4>:070==>AB8 A), AB5?5=L >1>1I5=8O -1. <p><b>8?84K, ;8?>?@>B58=K</b></p> <p align=justify>?B8<0;L=K5 C@>2=8 ;8?84>2 8 ;8?>?@>B58=>2 C 65=I8=: %!  <100 <3/4; (<2,6 <<>;L/;), %!  >50 <3/4; (>1,3 <<>;L/;), B@83;8F5@84>2 <150 <3/4; (<1,7 <<>;L/;), 8 =5- %! (>1I89 %!  %! ) <130 <3/4; (<3,34 <<>;L/;). !;54C5B ?>>I@OBL 4>AB865=85 MB8E C@>2=59 A ?><>ILN 87<5=5=89 >1@070 687=8. (;0AA I,C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -1. <p><b>8?84K  87<5=5=85 ?8B0=8O (485B>B5@0?8O) </b></p> <p align=justify># 65=I8= A 2KA>:8< @8A:><, 8;8 :>340 :>=F5=B@0F8O %!  2 :@>28 ?>2KH5=0, ?>B@51;5=85 =0AKI5==KE 68@>2 4>;6=> 1KBL <7% :0;>@89=>AB8 ACB>G=>3> @0F8>=0, ?8I52>3> E>;5AB5@8=0 <200 <3 2 45=L. @><5 B>3>, A;54C5B A>:@0B8BL ?>ABC?;5=85 A ?8I59 B@0=A<5@=KE 68@=KE :8A;>B (;0AA I, C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -1. <p><b>8?84K  D0@<0:>B5@0?8O  2KA>:89 @8A:*</b></p> <p align=justify># 65=I8= A 2KA>:8< @8A:>< 8 C@>2=5< %!  e"100 <3/4; (e"2,6 <<>;L/;) B5@0?8N 4;O A=865=8O %!  (?@54?>GB8B5;L=K AB0B8=K) A;54C5B =0G0BL >4=>2@5<5==> A <>48D8:0F859 >1@070 687=8 (;0AA I, #@>25=L 4>:070==>AB8 A), AB5?5=L >1>1I5=8O-1. # 65=I8= A 2KA>:8< @8A:>< 8 C@>2=5< %!  <100 <3/4; (2,6 <<>;L/;) ?@8 >BACBAB288 ?@>B82>?>:070=89 B0:65 A;54C5B =0G0BL B=@0?8N AB0B8=0<8 (;0AA I, #@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O-1. <p align=justify># 65=I8= A 2KA>:8< @8A:>< A;54C5B =07=0G0BL 2 8 =87:8< C@>2=5< %! , 8;8 ?>2KH5==K< C@>2=5< =5- %! =C46=> =0G0BL B5@0?8N =8:>B8=>2>9 :8A;>B>9 (=80F8=><) § 8;8 D81@0B0<8. (;0AA I, C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -1. <p><b>8?84K  D0@<0:>B5@0?8O  ?@><56CB>G=K9 @8A: </b></p> <p align=justify>A;8 =0 D>=5 <>48D8:0F88 >1@070 687=8 (B5@0?88, =0?@02;5==>9 =0 <>48D8:0F8N >1@070 687=8) C@>25=L %!  e"130 <3/4; (e" 3,34 <<>;L/;), A;54C5B =07=0G0BL ;5G5=85 =0?@02;5==>5 =0 A=865=85 %!  (?@54?>GB8B5;L=K AB0B8=K) ;0AA I, #@>25=L 4>:070==>AB8 A), AB5?5=L >1>1I5=8O-1,. >A;5 4>AB865=8O F5;52>3> C@>2=O %! , 2 A;CG0OE, 5A;8 A=865=0 :>=F5=B@0F8O %! , 8;8 ?>2KH5= C@>25=L =5- %!, @5:><5=4>20=> ?@8<5=5=85 =8:>B8=>2>9 :8A;>BK (=80F8=0)§ 8;8 D81@0B>2. (;0AA I, C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -1. <p><b>8?84K  D0@<0:>B5@0?8O - =87:89 @8A:! </b></p> <p align=justify># 65=I8= A =87:8< @8A:>< ! A;54C5B @0AA<>B@5BL B5@0?8N, =0?@02;5==CN =0 A=865=85 %! : <ul> <li>?@8 %!  e"190 <3/4; (e"4,9 <<>;L/;), 5A;8 4@C38E D0:B>@>2 @8A:0 =5B 8;8 8<55BAO B>;L:> >48=; <li>?@8 %!  e"160 <3/4; (e"4,1 <<>;L/;), 5A;8 8<55BAO =5A:>;L:> D0:B>@>2 @8A:0 (;0AA IIa, C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -1. </ul> <p align=justify>>A;5 4>AB865=8O F5;52KE C@>2=59 %! , ?@8 =87:>9 :>=F5=B@0F88 %!  8;8 ?@8 ?>2KH5==>< C@>2=5 =5- %!, <>6=> @0AA<>B@5BL B5@0?8N =8:>B8=>2>9 :8A;>B>9 (=80F8=><)§ 8;8 D81@0B0<8. (;0AA IIa, C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -1. <p><b>8015B</b></p> <p align=justify># 65=I8= A A0E0@=K< 48015B>< 4>;6=0 1KBL >ACI5AB2;5=0 <>48D8:0F8O >1@070 687=8 8 8A?>;L7>20=0 D0@<0:>B5@0?8O 4;O 4>AB865=8O 1;87:>3> : =>@<0;L=><C C@>2=N 3;8:>78;8@>20==>3> 35<>3;>18=0 (HbA1C <7%). (;0AA I, C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -1. <p align=center><u><b>548:0<5=B>7=0O ?@>D8;0:B8:0</b></u></p> <p><b>A?8@8=  2KA>:89 @8A:*</b></p> <p align=justify># 65=I8= A 2KA>:8< @8A:>< ?@8 >BACBAB288 ?@>B82>?>:070=89, 4>;65= 1KBL ?@8<5=5= 0A?8@8= 2 4>75 75 -162 <3 2 ACB, 0 2 A;CG05 =5?5@5=>A8<>AB8 0A?8@8=0 - :;>?84>3@5;L (;0AA I, C@>25=L 4>:070==>AB8 A), AB5?5=L >1>1I5=8O -1. <p><b>A?8@8=  ?@><56CB>G=K9 @8A: </b></p> <p align=justify>!;54C5B @0AA<>B@5BL B5@0?8N 0A?8@8=>< 2 4>75 75-162 <3 2 45=L C 65=I8= A ?@><56CB>G=K< @8A:><, 5A;8 4>AB83=CB :>=B@>;L 0@B5@80;L=>3> 402;5=8O, 8 5A;8 25;8:0 25@>OB=>ABL B>3>, GB> >68405<0O ?>;L70 >B ?@8<5=5=8O 0A?8@8=0 ?5@525A8B @8A: 65;C4>G=>-:8H5G=KE >A;>6=5=89. (;0AA IIa, C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -2. <p><b>5B0 - 1;>:0B>@K</b></p> <p align=justify>5B0 1;>:0B>@K 4>;6=K ?@8<5=OBLAO =5>?@545;5==> 4>;3> C 2A5E 65=I8=, ?5@5=5AH8E 8=D0@:B <8>:0@40, 8;8 8<5NI8E E@>=8G5A:85 8H5<8G5A:85 A8=4@><K (E@>=8G5A:CN !) ?@8 >BACBAB288 ?@>B82>?>:070=89. (;0AA I, C@>25=L 4>:070==>AB8 A), AB5?5=L >1>1I5=8O -1. <p><b>=3818B>@K $</b></p> <p align=justify>=3818B>@K $ A;54C5B ?@8<5=OBL C 65=I8= A 2KA>:8< @8A:><* ?@8 >BACBAB288 ?@>B82>?>:070=89. (;0AA I, C@>25=L 4>:070==>AB8 A), AB5?5=L >1>1I5=8O -1. <p><b>;>:0B>@K @5F5?B>@>2 : 0=38>B5=78=C</b></p> <p align=justify>;>:0B>@K @5F5?B>@>2 : 0=38>B5=78=C A;54C5B ?@8<5=OBL 2 A;CG05 =5?5@5=>A8<>AB8 8=3818B>@>2 $ C 65=I8= A 2KA>:8< @8A:>< 8 A :;8=8G5A:8<8 ?@87=0:0<8 A5@45G=>9 =54>AB0B>G=>AB8 8;8 A> A=865==>9 (<40%) D@0:F859 2K1@>A0. (;0AA I, #@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -1. <p align=center><u><b>5@F0B5;L=0O 0@8B<8O/ ?@54C?@5645=85 8=AC;LB0</b></u></p> <p><b>0@D0@8=  <5@F0=85 ?@54A5@489</b></p> <p align=justify># 65=I8= A ?>AB>O==>9 8;8 ?0@>:A87<0;L=>9 <5@F0B5;L=>9 0@8B<859 4>;65= 8A?>;L7>20BLAO 20@D0@8= 4;O ?>445@60=8O  (<564C=0@>4=>3> =>@<0;87>20==>3> >B=>H5=8O) =0 C@>2=5 2,0  3,0. A:;NG5=85: 65=I8=K ;81> A =87:8< @8A:>< <>73>2>3> 8=AC;LB0 (<1%/70 3>4), ;81> A 2KA>:8< @8A:>< :@>2>B5G5=89. (;0AA I, C@>25=L 4>:070==>AB8 A), AB5?5=L >1>1I5=8O -1. <p><b>A?8@8=  <5@F0B5;L=0O 0@8B<8O</b></p> <p align=justify>A?8@8= (325 <3/ACB) C 65=I8= A ?0@>:A87<0;L=>9 8;8 ?>AB>O==>9 <5@F0B5;L=>9 0@8B<859 A;54C5B ?@8<5=OBL, 5A;8 ?@>B82>?>:070= 20@D0@8=, 8;8 ?@8 =87:>< @8A:5 (<1%/70 3>4) <>73>2>3> 8=AC;LB0 (;0AA I, C@>25=L 4>:070==>AB8 A), AB5?5=L >1>1I5=8O -1 <p align=center><u><b><5H0B5;LAB20 III :;0AA0</b></u></p> <p><b>>@<>=0;L=0O B5@0?8O</b></p> <p align=justify># 65=I8= 2 ?>AB<5=>?0C75 =5 A;54C5B =0G8=0BL :><18=8@>20==CN 3>@<>=0;L=CN B5@0?8N MAB@>35=>< 8 ?@>35AB8=>< A F5;LN ?@>D8;0:B8:8 A5@45G=>-A>AC48ABKE 701>;520=89. (;0AA III, C@>25=L 4>:070==>AB8 A). <p align=justify># 65=I8= 2 ?>AB<5=>?0C75 =5 A;54C5B ?@>4>;60BL =0G0BCN @0=55 :><18=8@>20==CN 3>@<>=0;L=CN B5@0?8N MAB@>35=>< 8 ?@>35AB8=>< 4;O ?@>D8;0:B8:8 A5@45G=>-A>AC48ABKE 701>;520=89. (;0AA III, C@>25=L 4>:070==>AB8 C). <p align=justify># 65=I8= 2 ?>AB<5=>?0C75 =5 A;54C5B =0G8=0BL 8;8 ?@>4>;60BL 4@C385 284K 70<5AB8B5;L=>9 3>@<>=0;L=>9 B5@0?88 (B.5. =5C@02=>25H5==K5 MAB@>35=K) A F5;LN ?@>D8;0:B8:8 A5@45G=>-A>AC48ABKE 701>;520=89 2?;>BL 4> ?>O2;5=8O @57C;LB0B>2 5I5 =5 7025@H5==KE 8AA;54>20=89. (;0AA III, C@>25=L 4>:070==>AB8 C). <p><b>=B8>:A840=B=K5 4>102:8</b></p> <p align=justify>5 A;54C5B ?@8<5=OBL 0=B8>:A840=B=K5 28B0<8==K5 4>102:8 A F5;LN ?@>D8;0:B8:8 A5@45G=>-A>AC48ABKE 701>;520=89 4> ?>O2;5=8O @57C;LB0B>2 5I5 =57025@H5==KE 8AA;54>20=89. (;0AA III, C@>25=L 4>:070==>AB8 A), AB5?5=L >1>1I5=8O -1. <p><b>A?8@8=  =87:89 @8A:! </b></p> <p align=justify>5 @5:><5=4C5BAO @CB8==>5 ?@8<5=5=85 0A?8@8=0 C 65=I8= A =87:8< @8A:>< 2?;>BL 4> ?>;CG5=8O @57C;LB0B>2 5I5 =57025@H5==KE 8AA;54>20=89. (;0AA III, C@>25=L 4>:070==>AB8 B), AB5?5=L >1>1I5=8O -2. <p>@8<5G0=85:</p> § - 8:>B8=>20O :8A;>B0, 4>102;O5<0O : ?8I52K< ?@>4C:B0<, 8;8 ?@8=8<05<0O :0: 28B0<8=, =5 <>65B 70<5=8BL A>>B25BAB2CNI55 ;5:0@AB2> (=80F8= 8;8 4@C385 ?@5?0@0BK). 80F8= (=8:>B8=>20O :8A;>B0), ?@>40205<K9 157 @5F5?B0, A;54C5B ?@8<5=OBL B>;L:> 2 B>< A;CG05, 5A;8 >= =07=0G5=85 8 :>=B@>;L ;5G5=8O >ACI5AB2;ONBAO 2@0G><. <p>!>:@0I5=8O 8 CA;>2=K5 >1>7=0G5=8O:</p> GI  generalizability index - AB5?5=L >1>1I5=8O (8=45:A @0A?@>AB@0=5=8O 40==KE =0 65=I8=, >B=>H5=8O 8E : 65=I8=0<) (A<. B01;. 2); <br>%!   E>;5AB5@8= ;8?>?@>B58=>2 =87:>9 ?;>B=>AB8; <br>%!   E>;5AB5@8= ;8?>?@>B58=>2 2KA>:>9 ?;>B=>AB8; <br>$  0=38>B5=78= ?@52@0I0NI89 D5@<5=B; <br>!  :>@>=0@=0O 1>;57=L A5@4F0. <br>! - 8H5<8G5A:0O 1>;57=L A5@4F0. </p> </td></tr> </table> <!----- info table end ------------> </body> </HTML>